Belladonna Alkaloid Combinations and Phenobarbital

Why is this medication prescribed?
The combinations of belladonna and phenobarbital alkaloids are used to relieve cramping pain in conditions such as irritable bowel syndrome and spastic colon. They are also used with other medications to treat ulcers. These medications decrease the movement of the stomach and intestines and the secretion of stomach fluids, including acid.

This medication is sometimes prescribed for other uses; Ask your doctor or pharmacist for more information.

How should this medicine be used?
The combinations of belladonna alkaloids and phenobarbital come as a normal tablet, a slow-acting tablet, a capsule, and a liquid to take by mouth. The normal tablet, capsule, and liquid are usually taken three to four times a day, 30 minutes before meals and at bedtime. The slow-acting tablet is usually taken two to three times a day at evenly spaced intervals. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. Take the combinations of belladonna and phenobarbital alkaloids exactly as directed. Do not take more or less or take it more often than prescribed by your doctor.

Phenobarbital can create habit. Do not take a higher dose, take it more often or for a longer period than your doctor tells you. Signs of overdose are headache, nausea, vomiting, dizziness, blurred vision, dilated pupils in the eye, hot and dry skin, dry mouth, agitation, and difficulty swallowing. If you have any of these symptoms, stop taking belladonna and phenobarbital alkaloids and call your doctor immediately.

What special precautions should I follow?

Before taking belladonna alkaloid combinations and phenobarbital,

  • Tell your doctor and pharmacist if you are allergic to belladonna, any medications containing barbiturates, tartrazine (a yellow tint in some processed foods and medications) or any medications.
  • Tell your doctor and pharmacist what prescription and over-the-counter medications you are taking, especially any anticonvulsant medications, digoxin (Lanoxin), and vitamins. Antacids can decrease the effectiveness of this medication, so do not take antacids within 1 hour of taking it.
  • Tell your doctor if you have or have ever had glaucoma; an enlarged prostate; intestinal blockage Myasthenia gravis; Hiatal hernia; ulcerative colitis (a condition that causes swelling and sores in the lining of the colon [large intestine] and rectum); kidney, heart, or liver disease; urinary tract diseases; or high blood pressure
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking belladonna and phenobarbital alkaloids, call your doctor.
  • Talk to your doctor about the risks and benefits of taking this medication if you are 65 years of age or older. Older adults should receive low doses of belladonna and phenobarbital because higher doses do not work better and can cause serious side effects.
  • You should know that this medicine can cause drowsiness. Do not drive a car or operate machinery until you know how this medicine affects you.
  • Remember that alcohol can increase drowsiness caused by this medicine.
  • You should know that belladonna alkaloids can decrease sweating and cause heat stroke. Be careful to overheat during exercise and in hot weather.
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What should I do if I forget a dose?
Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

To avoid dry mouth or throat, chew gum or suck sugarless hard candies. To avoid increased eye sensitivity to light, wear sunglasses. Tell your doctor if any of these symptoms are severe or do not go away:

  • confusion
  • constipation
  • blurred vision
  • dizziness
  • drowsiness
  • nervousness
  • skin flushing

If you experience any of the following symptoms, call your doctor immediately:

  • eye pain
  • rapid heartbeat
  • skin rash
  • difficulty urinating
  • lack of sweating in hot weather

If you experience a serious side effect, you or your doctor can submit an online report to the Food and Drug Administration (FDA) MedWatch Adverse Event Reporting Program ( or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?
Keep this medicine in its container, tightly closed and out of the reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unnecessary medications must be disposed of in a special way to ensure that pets, children and others cannot consume them. However, you should not flush this medicine down the toilet. Instead, the best way to get rid of your medication is through a medication take-back program. Talk to your pharmacist or contact your local garbage / recycling department for information on return programs in your community. Consult the FDA’s Safe Drug Disposal website ( for more information if you do not have access to a take-back program.

It is important to keep all medications out of the sight and reach of children, as many containers (such as those for taking pills weekly and those used for eye drops, creams, patches, and inhalers) are not resistant to children and children. young children can easily open them. To protect young children from poisoning, always close the safety caps and immediately put the medicine in a safe place, one that is up and away and out of your sight and reach.

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In case of emergency/overdose
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim collapsed, had a seizure, is having trouble breathing, or cannot wake up, call 911 immediately.

What other information should I know?
Keep all your appointments with your doctor.

Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.

It is important that you keep a written list of all prescription and over-the-counter (non-prescription) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should carry this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names of combination products

  • Donnatal® Tablets (containing Atropine, Hyoscyamine, Phenobarbital, Scopolamine)
  • Donnatal® Elixir (containing Atropine, Hyoscyamine, Phenobarbital, Scopolamine)
  • PB Hyos® Elixir (containing Atropine, Hyoscyamine, Phenobarbital, Scopolamine)
  • Quadrapax® Elixir (containing Atropine, Hyoscyamine, Phenobarbital, Scopolamine)

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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