Cablivi Injection : Uses, Side Effects, Interactions & More

Why is this medication prescribed?

Cablivi (Caplacizumab-yhdp) injection is used to treat acquired thrombotic thrombocytopenic purpura (aTTP; a disorder in which the body attacks itself and causes clots, low numbers of platelets and red blood cells, and could cause other serious complications) in combination with plasma exchange therapy and immunosuppressive drugs. Cablivi belongs to a class of medications called antithrombotic agents. It works by blocking the action of a certain substance in the body that causes the symptoms of aTTP.

How should this medicine be used?

Cablivi (Caplacizumab-yhdp) comes as a powder that dissolves in a liquid and is given intravenously (into the vein) or subcutaneously (under the skin). It is usually given on the first day of treatment as an intravenous injection at least 15 minutes before plasma exchange and then again as a subcutaneous injection after plasma exchange is complete. After the first day of treatment, it is usually given as a subcutaneous injection once a day after plasmapheresis for as long as you receive plasmapheresis therapy and then once a day for an additional 30 to 58 days after stopping plasmapheresis therapy. . Use Cablivi at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any parts you don’t understand. Use Cablivi exactly as directed. Do not use more or less or use it more often than prescribed by your doctor.

Your doctor may allow you or a caregiver to do the injections at home. Ask your doctor or pharmacist to show you or the person who will give the injections how to prepare and inject Cablivi. Before you use Cablivi injection yourself for the first time, read the written instructions that come with it. Ask your pharmacist or physician for a copy of the manufacturer’s instructions for patient use information.

Cablivi injection should be injected subcutaneously into the abdominal area (stomach) but avoid the belly button and the area of ​​2 inches (5 centimeters) around it. Do not inject in the same place two days in a row.

Dispose of used needles, syringes, and vials in a puncture-resistant container. Talk to your doctor or pharmacist about how to dispose of the puncture resistant container.

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Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before receiving Cablivi,

  • Tell your doctor and pharmacist if you are allergic to Cablivi, any other medications, or any of the ingredients in Cablivi injection. Ask your pharmacist for a list of the ingredients.
  • Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: apixaban (Eliquis), clopidogrel (Plavix), dabigatran (Pradaxa), dipyrimadole (Persantine, in Aggrenox), edoxaban (Savaysa), enoxaparin (Lovenox), fondaparinux (Arixtra), heparrelin, prasugrelin ( Effient), rivaroxaban (Xarelto), ticagrelor (Brilinta), or warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you closely for side effects.
  • Tell your doctor if you have or have ever had hemophilia (a genetic disorder in which the body cannot stop bleeding properly) or other bleeding problems or liver disease.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while receiving Cablivi, call your doctor.
  • If you are having surgery, including dental surgery, tell the doctor or dentist that you are using Cablivi. Your doctor or dentist may tell you not to use Cablivi for 7 days before your surgery.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Use the missed dose as soon as you remember. However, if you are no longer receiving plasma exchange therapy and it has been more than 12 hours since the missed dose, skip the missed dose and continue your regular dosing schedule. Do not use a double dose to make up for the one you forgot.

What side effects can this medication cause?

Cablivi may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache
  • extreme tiredness
  • back pain
  • muscle pain
  • tingling, prickling, or numb feeling on the skin
  • itching near the spot the medication was injected
  • shortness of breath
  • fever
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Some side effects can be serious. If you experience any of these symptoms call your doctor immediately or get emergency medical treatment:

  • hives
  • heavy bleeding that won’t stop including bleeding from rectum, vagina, nose, gums or place where the medication was injected
  • vomiting blood
  • red, or black, tarry stools
  • blood in urine
  • sudden severe headache, nausea, vomiting
  • sudden, sharp abdominal pain, nausea, vomiting
  • frequent, painful, or urgent urination

Cablivi injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medicine.

If you experience a serious side effect, you or your doctor can submit a report online to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program ( or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medicine in the container it came in, tightly closed, and out of the reach of children. Store it in the refrigerator and protected from light. Do not freeze. Cablivi injection can be kept at room temperature for up to 2 months, but should be kept in the original carton to protect from light. Cablivi should not be returned to the refrigerator after it has been stored at room temperature.

It is important to keep all medicines out of the sight and reach of children, since many containers (such as those containing weekly pills and those for eye drops, creams, patches and inhalers) are not resistant to children and small children can easily open them. To protect young children from poisoning, always close the safety caps and immediately place the medicine in a safe place, one that is upright and out of their sight and reach.

Unnecessary medications must be disposed of in special ways to ensure that pets, children, and others cannot consume them. However, you should not flush this medicine down the toilet. Instead, the best way to dispose of your medications is through a drug take-back program. Talk to your pharmacist or contact your local garbage / recycling department to find out about take-back programs in your community. See the FDA Safe Drug Disposal website ( for more information if you do not have access to a take-back program.

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In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim collapsed, had a seizure, has trouble breathing, or cannot wake up, immediately call 911 for emergency services.

Symptoms of overdose may include:

  • bleeding

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain laboratory tests to see if Cablivi treatment should be continued.

Don’t let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important to keep a written list of all prescription and over-the-counter (over-the-counter) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should take this list with you every time you visit a doctor or if you go into hospital. It is also important information to take with you in case of emergencies.

Brand Names

  • Cablivi®

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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