Diaminodiphenylsulfone : Uses, Side Effects, Interactions & More

Why is this medication prescribed?

Diaminodiphenylsulfone (Dapsone) is used to treat leprosy and skin infections.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?

Diaminodiphenylsulfone (Dapsone) comes as a tablet to take by mouth. Diaminodiphenylsulfone usually is taken either once a day or three times a week. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take diaminodiphenylsulfone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

What special precautions should I follow?

Before taking diaminodiphenylsulfone,

• tell your doctor and pharmacist if you are allergic to diaminodiphenylsulfone, sulfa drugs, phenylhydrazine, naphthalene, niridazole, nitrofurantoin, primaquine, or any other drugs.
• tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially aminobenzoate potassium (Potaba), aminobenzoic acid, clofazimine (Lamprene), didanosine (Videx), probenecid (Benemid), pyrimethamine (Daraprim), rifampin (Rifadin), trimethoprim (Bactrim, Cotrim, Septra), or vitamins.
• tell your doctor if you have or have ever had anemia or liver disease.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking diaminodiphenylsulfone, call your doctor.
• plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Diaminodiphenylsulfone may make your skin sensitive to sunlight.

What special dietary instructions should I follow?

Diaminodiphenylsulfone may cause an upset stomach. Take diaminodiphenylsulfone with food or milk.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Diaminodiphenylsulfone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• upset stomach
• vomiting

If you experience any of the following symptoms, call your doctor immediately:

• sore throat
• fever
• rash
• yellowing of the skin or eyes
• unusual bruising

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to diaminodiphenylsulfone.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

• Dapsone

Other names

• DDS
• diaminodiphenylsulfone

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.