Paraplatin : Uses, Side Effects, Interactions & More

IMPORTANT WARNING:

Paraplatin injection (Carboplatin Injection) should be administered in a hospital or medical facility under the supervision of a physician experienced in administering chemotherapy drugs for cancer.

Paraplatin can cause a severe decrease in the number of blood cells in your bone marrow. This increases your risk of developing a serious infection or bleeding. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, chills, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising; black, tarry stools; red blood in the stool; vomit with blood; vomited material that looks like coffee grounds.

Paraplatin can cause serious allergic reactions. If you experience an allergic reaction to Paraplatin injection, it may start a few minutes after the infusion begins and you may experience the following symptoms: hives; acne; itching; redness of the skin; difficulty breathing or swallowing; dizziness; weakness; or fast heartbeat. Tell your doctor immediately if you experience any of these symptoms.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before, during, and after your treatment to check your body’s response to Paraplatin. Your doctor may need to stop or delay your treatment if you experience certain side effects.

Why is this medication prescribed?

Paraplatin (Carboplatin Injection) is used alone or in combination with other medications to treat cancer of the ovaries (cancer that begins in the female reproductive organs where eggs are formed) that has spread to other parts of the body, not improved, or that has worsened after treatment with other medications or radiation therapy. Paraplatin is in a class of medications known as platinum-containing compounds. It works by stopping or slowing the growth of cancer cells.

How should this medicine be used?

Paraplatin injection comes as a solution (liquid) that must be injected intravenously (into a vein) over at least 15 minutes by a doctor or nurse at a medical facility. It is usually given once every 4 weeks.

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Other uses for this medicine

Paraplatin is also sometimes used to treat lung, bladder, breast, and endometrial cancer; Head and neck cancer; cancer of the cervix and testicles: Wilms tumor (a type of kidney cancer that occurs in children); certain types of brain tumors; neuroblastoma (a cancer that begins in nerve cells and occurs mainly in children); and retinoblastoma (eye cancer). Talk to your doctor about the risks of using this drug for your condition.

This medicine may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before receiving Paraplatin injection,

  • Tell your doctor and pharmacist if you are allergic to Paraplatin, cisplatin (Platinol), any other medications, or any of the ingredients in Paraplatin injection. Ask your pharmacist for a list of the ingredients.
  • Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminoglycoside antibiotics such as amikacin (Amikin), gentamicin (Garamycin), or tobramycin (Tobi, Nebcin). Your doctor may need to change the doses of your medications or monitor you closely for side effects. Many other medications can also interact with cisplatin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • Tell your doctor if you have or have ever had kidney disease or if you have bleeding problems.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. You should not become pregnant or breastfeed while you are receiving Paraplatin. If you become pregnant while receiving Paraplatin, call your doctor. Paraplatin can harm the fetus.
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What side effects can this medication cause?

Paraplatin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • diarrhea
  • constipation
  • sores in the mouth and throat
  • pain, burning, or tingling in the hands or feet
  • pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected
  • hair loss
  • pain
  • weakness
  • loss in ability to taste food

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

  • pale skin
  • unusual tiredness or weakness
  • fainting
  • dizziness
  • sudden changes in vision, including color vision
  • decreased urination
  • swelling of the face, arms, hands, feet, ankles, or lower legs
  • shortness of breath with everyday activity or when lying flat
  • ringing in ears and difficulty hearing

Paraplatin can increase your risk of developing other cancers. Talk to your doctor about the risks of taking this medicine.

Paraplatin can cause other side effects. Call your doctor if you have any unusual problems while taking this medicine.

If you experience a serious side effect, you or your doctor can submit a report online to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim collapsed, had a seizure, has trouble breathing, or cannot wake up, immediately call 911 for emergency services.

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Symptoms of overdose may include:

  • black, tarry, or bloody stools
  • bloody vomit or vomited material that looks like coffee grounds
  • unusual bruising or bleeding
  • decreased urination
  • pain, burning, or tingling in the hands or feet
  • ringing in ears and difficulty hearing

What other information should I know?

It is important that you keep a written list of all prescription and over-the-counter (over-the-counter) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should take this list with you each time you visit a doctor or if you go into hospital. It is also important information to take with you in case of emergencies.

Brand Names

  • Paraplatin®

Other Names

  • CBDCA

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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