Azilect Oral : Uses, Side Effects, Interactions
GENERIC NAME(S): Rasagiline
Rasagiline, sold under the trade name Azilect among others. Azilect is used alone or with other medicines (such as levodopa/carbidopa) to treat symptoms of Parkinson’s disease. It can help improve symptoms such as closeness, hardness and difficulty moving. It can also help reduce the amount of “off” time (slow speed or duration of immobility).
Azilect comes under a category of drugs known as MAO inhibitors. It works by increasing the levels of some natural substances in the brain (such as dopamine, norepinephrine, serotonin). It is believed that Parkinson’s disease is due to very low dopamine in the brain.
How to use Azilect
Directly medicate this medicine with your mouth or without food, usually daily once.
Dosage is based on your medical condition, reaction to treatment and other medicines you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including Prescription Drugs, nonprescription Drugs and Herbal Products). Do not increase your dose or take it more than it has been fixed. There will be no improvement in your situation, and the risk of your side effects will increase.
Do not stop taking this medicine without consultation with your doctor. When this medicine suddenly stops, some conditions may get worse. Your dose may need to be gradually decreased.
The reaction of very serious hypertension can rarely occur if you eat Azilect and eat tyramine in large quantities for 2 weeks after it is stopped. Avoid foods that are high in tyramine, such as old things (such as Stilton cheese). Consult with your doctor or dietician what foods you should avoid and if you do not feel good after eating or drinking some foods while taking this medicine. See also the Side Effects section.
Tell your doctor if this medicine stops working well or if your condition worsens.
Dizziness, drowsiness, pain in joints, heartburn, nausea, dry mouth, loss of weight or pain in the stomach / stomach. If any of these effects gets worse or worse, then tell your doctor or pharmacist immediately.
Remember that your doctor has prescribed this drug because he or she has decided that the benefit is higher than the risk of side effects. Many people using this drug do not have serious side effects.
Tell your doctor immediately if you have any serious side effects, including: unconsciousness, loss of balance, changes in mental / mood (such as confusion, depression, hallucinations), deteriorating muscle stiffness / twitch / uncontrollable movement, swollen ankle / Feet, easy bleeding / injury, abnormal strong insistence (such as increased gambling, sexual urges increases).
Some people who take Azilect have suddenly slept during their usual daily activities (such as talking on the phone, driving). In some cases, sleep has already happened without feelings of sleepiness. This sleep effect can occur at any time during the treatment with Azilect, even if you have used this medicine for a long time. If you experience an increase in sleep during the day or fall asleep, do not drive or participate in other potentially dangerous activities, unless you have discussed this effect with your doctor. Your risk of the effect of this sleep increases with the use of alcohol or other medicines that can make you dull. See also the Precautions section.
This drug can increase serotonin and rarely cause a very serious condition, which is called serotonin syndrome / toxicity. The risk increases if you are taking other medicines which increase the serotonin, so tell your doctor or pharmacist about all the medicines that you take. Get medical help immediately when some of the following symptoms develop: Fast heartbeats, hallucinations, loss of coordination, severe dizziness, severe nausea / vomiting / diarrhea, muscle shaking, unexplained fever, abnormal movement or restlessness
Azilect can rarely cause the attack of hypertension (high blood pressure), which can be fatal. Many drug and food interactions can increase this risk (see how to use and drug interaction section). If any of these have serious side effects, seek medical help immediately: severe headache, fast / slow / irregular / fast heartbeat, chest pain, neck / cramps, severe nausea / vomiting, sweating / smelly skin (sometimes- Occasionally due to fever), broad pupils, vision changes (such as double / blurred vision), sudden sensitivity towards light (photophobia)
A very serious allergic reaction to this drug is rare. However, if you see symptoms of a serious allergic reaction, get medical help immediately, including: granular, itching / swelling (especially the face / tongue / throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you do not list other effects above, contact your doctor or pharmacist.
In America – Call your doctor for medical advice about side effects. You can notify the FDA of side effects on 1-800-FDA-1088 or www.fda.gov/medwatch.
In Canada – Call your doctor for medical advice about side effects. You can report the health effects of Canada on 1-866-234-2345.
Before taking Azilect or Rasagiline, tell your doctor or pharmacist whether you are allergic to it; Or if you have any other allergens. This product can have passive elements, which can cause allergic or other problems. Talk to your pharmacist for more details.
Before using this drug, tell your doctor or pharmacist your medical history, especially: heart disease (such as coronary artery disease, heart attack, chest pain, heart failure), stroke, high blood pressure, severe / Persistent headache, liver disease, mental / mood disorders (such as schizophrenia, bipolar disorder, depression), diabetes, overactive thyroid, a certain kind of adrenal gland tumor (pheochromocytoma), sleep disorders.
Azilect may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or deaf. Unless you can safely do it, do not drive, use machinery, or do anything that requires caution. Limit alcoholic beverages. If you are using marijuana, talk to your doctor. See also the Side Effects section.
Before surgery, tell your doctor or dentist about all the products that you use (including prescription drugs, nonprescription drugs and herbal products).
During pregnancy, this drug should be used only when it is clearly necessary. Discuss the risks and benefits with your doctor.
It is unknown if this medicine passes in breast milk. Consult your doctor before breastfeeding.
See also the usage section.
Drug interactions can change how your medicines work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescriptions / non-prescription medicines and herbal products) and share it with your doctor and pharmacist. Do not start, stop or change any drug supplements without the approval of your doctor.
Some products that may interact with this drug include: diet pills/appetite suppressants (such as diethylpropion), drugs for attention deficit disorder (such as atomoxetine, methylphenidate), apraclonidine, bupropion, buspirone, carbamazepine, cyclobenzaprine, deutetrabenazine, dextromethorphan, methyldopa, certain supplements (such as tryptophan, tyramine), tetrabenazine, certain “triptans” used to treat migraine headaches (such as rizatriptan, sumatriptan, zolmitriptan), valbenazine.
The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/”ecstasy,” St. John’s wort, tramadol, certain narcotic medications (such as fentanyl, meperidine, methadone, tapentadol), certain antidepressants (including maprotiline, mirtazapine, SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine, tricyclics such as amitriptyline/doxepin), among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.
Some products, if you take them together, or even if you take them before or after taking Azilect, then you can talk with Azilect. Tell your doctor or pharmacist whether you take anything in the list of products that can interact with this drug, or any product that enhances serotonin, 2 weeks before or after taking Azilect. Also tell them whether you have taken fluoxetine within 5 weeks before starting Azilect. Ask your doctor how much time to wait for between starting or stopping any of these medicines and starting a Azilect.
Taking other MAO inhibitors with this drug can be a serious (potentially fatal) drug interaction. Do not take any other MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, safinamide, selegiline, tranylcypromine) during treatment with this drug. Most MAO inhibitors should not be taken for two weeks before and after treatment with this drug. Ask your doctor when to start or stop this medication.
Before using Azilect, report the use of drugs that may increase the risk of extremely high blood pressure (hypertensive crisis) when combined with Azilect, including herbal products (such as ephedra/ma Huang), allergy and cough-and-cold products (including dextromethorphan, decongestants such as phenylephrine/pseudoephedrine), and stimulants (such as amphetamines, ephedrine, epinephrine, phenylalanine). Azilect should not be used with any of these medications. Talk to your doctor or pharmacist for more details.
Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, marijuana, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants (such as carisoprodol), and narcotic pain relievers (such as codeine, hydrocodone).
If someone is treated and has serious symptoms like having trouble going out or breathing, call 911. Otherwise, call the Poison Control Center immediately. US residents can call their local venom control center at 1-800-222-1222. Canadians can call a provincial poison control center. Symptoms of overdose can not be visible for 12 hours and may include: irritability, restlessness, dizziness, drowsiness, sweating, heartbeat, headache, confusion, seizures.
Do not share this medication with others.
Labs and / or medical tests (like blood pressure) will be done when you are taking this medication. Keep all medical and lab appointments.
People with Parkinson’s disease can increase the risk of developing skin cancer (melanoma). Tell your doctor immediately if you have a mole that grows or looks different, or if you have any other unusual skin changes. Ask your doctor if your skin should be checked regularly.
If you miss a dose, then as soon as you remember, take it. If it is near the next dose time, then leave the thesis dose. Take your next dose at regular times. Do not double the dose to catch up.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Until instructed not to do so, do not flush the medicines in the toilet and do not drain in the drain. When this period expires or does not need it, then properly release this product. Consult your pharmacist or local waste disposal company.
Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.