Biktarvy : Uses, Side Effects, Interactions & More


Biktarvy should not be used to treat hepatitis B virus infection (HBV; an ongoing liver infection). Tell your doctor if you have or think you may have HBV. Your doctor may test you for HBV before starting your treatment with Biktarvy. If you have HBV and take Biktarvy, your condition may suddenly get worse when you stop taking Biktarvy.

Keep all appointments with your doctor and the laboratory. Your doctor will examine you and order lab tests before, during, and regularly for several months after you stop taking Biktarvy to see if your HBV has gotten worse.

Talk to your doctor about the risks of taking Biktarvy.

Why is this medication prescribed?

Biktarvy (The combination of bictegravir, emtricitabine, and tenofovir) is used to treat human immunodeficiency virus (HIV) infection in certain adults and children who weigh at least 55 pounds (25 kg) who have not received antiretroviral treatment in the past or who have been stable with other antiretroviral treatment (s). Bictegravir is in a class of drugs called integrase chain transfer inhibitors (INSTIs). Emtricitabine and tenofovir belong to a class of drugs called nucleoside analog reverse transcriptase inhibitors (NRTIs). The Biktarvy works by lowering the amount of HIV in the body. Although Biktarvy will not cure HIV, these medications can lower your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses, such as serious infections or cancer. Taking these medications along with safer sex and making other lifestyle changes can lower your risk of getting or passing the HIV virus to others.

How should this medicine be used?

Biktarvy (The combination of bictegravir, emtricitabine, and tenofovir) comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take Biktarvy at around the same times every day. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any parts you do not understand. Take Biktarvy exactly as directed. Do not take more or less, or take it more often than prescribed by your doctor.

Keep taking Biktarvy even if you feel fine. Do not stop taking Biktarvy without talking to your doctor. If you stop taking Biktarvy even for a short time, or skip doses, the virus may become resistant to the drugs and may be more difficult to treat.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

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Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking Biktarvy,

  • Tell your doctor and pharmacist if you are allergic to Biktarvy, any other medications, or any of the ingredients in Biktarvy tablets. Ask your pharmacist for a list of the ingredients.
  • Tell your doctor if you are taking dofetilide (Tikosyn) or rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Your doctor will probably tell you not to take Biktarvy if you are taking any of these medications.
  • Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: acyclovir (Zovirax); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); cidofovir; ganciclovir (Valcyte); gentamicin; other medicines to treat human immunodeficiency virus (HIV); metformin (Glucophage, Riomet); nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); Oxcarbazepine (Trileptal); phenobarbital; phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); rifapentine (Priftin); ritonavir (Norvir, in Kaletra); valacyclovir (Valtrex); and valganciclovir (Valcyte). Your doctor may need to change the doses of your medications or monitor you closely for side effects. Many other medications can also interact with Biktarvy, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • If you are taking an antacid that contains calcium, magnesium, aluminum (Maalox, Mylanta, Tums, others), or sucralfate (Carafate), take Biktarvy on an empty stomach 2 hours before you take the antacid or sucralfate.
  • If you are taking an iron or calcium supplement, take it at the same time as Biktarvy with food.
  • Tell your doctor what herbal products you are taking, especially St. John’s wort.
  • Tell your doctor if you have or have ever had the conditions mentioned in the IMPORTANT WARNING section or any type of infection that does not go away or that comes and goes such as tuberculosis (TB; a type of lung infection) or cytomegalovirus (CMV; an infection virus that can cause symptoms in people with weak immune systems) or kidney disease.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking Biktarvy, call your doctor. You should not breastfeed if you are infected with HIV or if you are taking Biktarvy.
  • You should know that while you are taking medicine to treat HIV infection, your immune system may get stronger and begin to fight other infections that were already in your body or cause other conditions to occur. This can cause you to develop symptoms of these infections or conditions. If you have new or worsening symptoms during your treatment with Biktarvy, be sure to tell your doctor.
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What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Biktarvy may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • diarrhea
  • nausea
  • vomiting
  • headache

If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

  • decreased urination
  • swelling of feet and ankles
  • fatigue
  • shortness of breath
  • fast breathing
  • fast or abnormal heartbeat
  • stomach pain with nausea and vomiting
  • cold or blue color of the hands and feet
  • dark yellow or brown urine
  • light-colored bowel movements
  • yellowing of skin or eyes
  • loss of appetite
  • weakness
  • fatigue
  • dizziness or lightheadedness

Biktarvy can cause other side effects. Call your doctor if you have any unusual problems while taking this medicine.

If you experience a serious side effect, you or your doctor can submit a report online to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program ( or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medicine in the container it came in, tightly closed, and out of the reach of children. Store at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medicines out of the sight and reach of children, as many containers (such as those containing weekly pills and those for eye drops, creams, patches and inhalers) are not child-resistant and small children can easily open them. To protect young children from poisoning, always close the safety caps and immediately place the medicine in a safe place, one that is upright and out of their sight and reach.

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Unnecessary medications must be disposed of in special ways to ensure they cannot be consumed by pets, children, and others. However, you should not flush this medicine down the toilet. Instead, the best way to dispose of your medications is through a drug take-back program. Talk to your pharmacist or contact your local garbage / recycling department to learn about take-back programs in your community. Check out the FDA drug safe disposal website ( for more information if you do not have access to a take-back program.

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim collapsed, had a seizure, is having trouble breathing, or is unable to wake up, immediately call 911 for emergency services.

What other information should I know?

Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.

Have a supply of Biktarvy on hand. Don’t wait until your medicine runs out to get a refill.

It is important that you keep a written list of all prescription and over-the-counter (over-the-counter) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should take this list with you every time you visit a doctor or if you go into hospital. It is also important information to take with you in case of emergencies.

Brand Names

  • Biktarvy®

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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