Bromocryptine : Uses, Side Effects, Interactions & More

Why is this medication prescribed?

Bromocryptine (Parlodel) is used to treat the symptoms of hyperprolactinemia (high levels of a natural substance called prolactin in the body), including missing menstrual periods, nipple discharge, infertility (difficulty getting pregnant), and hypogonadism ( low levels of certain natural substances). necessary for normal development and sexual function). Bromocryptine (Parlodel) can be used to treat hyperprolactinemia caused by certain types of prolactin-producing tumors and can shrink these tumors. Bromocryptine (Parlodel) is also used alone or with other treatments to treat acromegaly (a condition in which there is too much growth hormone in the body) and Parkinson’s disease (PD; a disorder of the nervous system that causes difficulties with movement. , muscle control, and balance). Bromocryptine (Cycloset) is used with a diet and exercise program and sometimes with other medications to control blood sugar levels in people with type 2 diabetes (a condition in which the body does not use insulin normally and therefore therefore, you cannot control the amount of sugar in your blood). ). Bromocryptine (Cycloset) is not used to treat type 1 diabetes (a condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that can develop if high blood sugar is not produced). treaty). Bromocryptine is in a class of medications called dopamine receptor agonists. Treats hyperprolactinemia by lowering the amount of prolactin in the body. Treats acromegaly by lowering the amount of growth hormone in the body. Treat Parkinson’s disease by stimulating the nerves that control movement. The way Bromocryptine works to treat diabetes is unknown.

How should this medicine be used?

Bromocryptine (Parlodel) comes as a capsule and tablet to take by mouth. Bromocryptine (Cycloset) comes as a tablet to take by mouth. When Bromocryptine (Parlodel) is used to treat hyperprolactinemia, it is usually taken once a day with food. When Bromocryptine (Parlodel) is used to treat acromegaly, it is usually taken once a day before going to bed with food. When Bromocryptine (Parlodel) is used to treat Parkinson’s disease, it is usually taken twice a day with food. Bromocryptine (Cycloset) is usually taken once a day with food within 2 hours of waking up in the morning. Take Bromocryptine at around the same time every day. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any parts you do not understand. Take Bromocryptine exactly as directed. Do not take more or less, or take it more often than prescribed by your doctor.

Your doctor will likely prescribe a low dose of Bromocryptine and increase it gradually, no more than once every 2 to 28 days. When to increase your dose depends on the condition being treated and your response to the medicine.

Bromocryptine can help control your condition, but it will not cure it. It may take some time for you to feel the full benefits of Bromocryptine. Do not stop taking Bromocryptine without consulting your doctor. If you stop taking Bromocryptine, your condition may get worse.

If you are taking Bromocryptine (Cycloset) for diabetes, ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

Other uses for this medicine

Bromocryptine should not be used to stop the production of breast milk in women who have had an abortion or stillbirth or who have chosen not to breastfeed; Bromocryptine can cause serious or fatal side effects in these women. Talk to your doctor about the possible risks of using this drug for your condition.

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This medicine may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking Bromocryptine,

  • Tell your doctor and pharmacist if you are allergic to Bromocryptine; Ergot alkaloids such as cabergoline (Dostinex), dihydroergotamine (DHE 45, Migranal), ergoloid mesylates (Germinal, Hydergine), ergonovine (Ergotrate), ergotamine (Bellergal-S, Cafergot, Ergomar, Wigraine) (methylergonovine) , Sansert) and pergolide (Permax); any other medication; or any of the ingredients in Bromocryptine tablets or capsules. Ask your pharmacist for a list of the ingredients.
  • Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amitriptyline (Elavil); antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); antihistamines; chloramphenicol; dexamethasone (Decadron, Dexpak); other dopamine agonists such as cabergoline (Dostinex), levodopa (Dopar, Larodopa), pergolide (Permax), and ropinirole (Requip); ergot-type medications such as dihydroergotamine (DHE 45, Migranal), ergoloid mesylates (Germinal, Hydergine), ergonovine (Ergotrate), ergotamine (Bellergal-S, Cafergot, Ergomar, Wigraine), methylergonovine (Methergine, Hydergine), and methyrolysis ); haloperidol (Haldol); imipramine (Tofranil); insulin; macrolide antibiotics such as clarithromycin (Biaxin, in PrevPac) and erythromycin (E.E.S., E-Mycin, Erythrocin); certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); oral medications for diabetes; medications for asthma, colds, high blood pressure, migraines, and nausea; medications for mental illness such as clozapine (Clozaril, FazaClo), olanzapine (Zyprexa, in Symbyax), thiothixene (Navane), and ziprasidone (Geodon); methyldopa (from Aldoril); metoclopramide (Reglan); nefazodone; Octreotide (Sandostatin); pimozide (Orap); probenecid (in Col-Probenecid, Probalan); reserpine; rifampicin (Rifadin, in Rifamate, in Rifater, Rimactane); and sumatriptan (Imitrex). Your doctor may need to change the doses of your medications or monitor you closely for side effects. Many other medications can also interact with Bromocryptine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • Tell your doctor if you have high blood pressure or migraines that cause you to pass out. Your doctor may tell you not to take Bromocryptine.
  • Tell your doctor if you have recently given birth, if you have ever fainted, and if you have or have ever had a heart attack; slow, fast, or irregular heartbeat; Mental illness; low blood pressure, ulcers; bleeding in the stomach or intestines; Raynaud’s syndrome (condition in which the hands and feet become numb and cool when exposed to cold temperatures); heart, kidney, or liver disease; or any condition that prevents you from digesting foods that contain sugar, starch, or dairy products normally.
  • Tell your doctor if you are pregnant or plan to become pregnant. If you are taking Bromocryptine (Parlodel) to treat missed menstrual periods and infertility caused by hyperprolactinemia, use a method of birth control other than hormonal contraceptives (birth control pills, patches, rings, or injections) until you have regular menstrual periods; then stop using birth control. You should have a pregnancy test once every 4 weeks as long as you are not menstruating. Once your menstrual period returns, you should take a pregnancy test every time your period is 3 days late. If you do not want to get pregnant, use a method of birth control other than hormonal contraceptives while you are taking Bromocryptine. If you become pregnant during your treatment with Bromocryptine, stop taking the medication and call your doctor.
  • Do not breastfeed while taking Bromocryptine.
  • If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Bromocryptine (Cycloset).
  • You should know that Bromocryptine can make you drowsy and suddenly fall asleep. Do not drive a car or operate machinery until you know how this medicine affects you.
  • Ask your doctor about the safe use of alcoholic beverages while taking Bromocryptine. Alcohol can make the side effects of Bromocryptine worse.
  • You should know that Bromocryptine can cause dizziness, nausea, sweating, and fainting when you get up too quickly from lying down. This is more common when you start taking Bromocryptine or when your dose is increased. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
  • Ask your doctor what to do if you get sick, develop an infection or fever, experience unusual stress, or are injured. These conditions can affect your blood sugar level and the amount of Bromocryptine (Cycloset) that you may need.
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What special dietary instructions should I follow?

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

Be sure to follow all of the diet and exercise recommendations made by your doctor or dietitian.

What should I do if I forget a dose?

If you take Bromocryptine (Parlodel), take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for the one you forgot.

If you take Bromocryptine (Cycloset) once a day and miss your morning dose, wait until the next morning to take your medicine. Do not take a double dose to make up for the one you forgot.

What side effects can this medication cause?

This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.

Bromocryptine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • diarrhea
  • constipation
  • stomach cramps
  • heartburn
  • loss of appetite
  • headache
  • weakness
  • tiredness
  • dizziness or lightheadedness
  • drowsiness
  • difficulty falling asleep or staying asleep
  • depression

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • fainting
  • watery discharge from the nose
  • numbness, tingling, or pain in your fingers especially in cold weather
  • black and tarry stools
  • bloody vomit
  • vomiting material that looks like coffee grounds
  • swelling of the feet, ankles, or lower legs
  • seizures
  • severe headache
  • blurred or impaired vision
  • slow or difficult speech
  • weakness or numbness of an arm or leg
  • chest pain
  • pain in the arms, back, neck or jaw
  • shortness of breath
  • confusion
  • hallucinations (seeing things or hearing voices that do not exist)

Bromocryptine can cause other side effects. Call your doctor if you have any unusual problems while taking this medicine.

If you experience a serious side effect, you or your doctor can submit a report online to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medicine in the container it came in, tightly closed, and out of the reach of children. Store at room temperature and away from light, excess heat, and moisture (not in the bathroom).

Unnecessary medications must be disposed of in special ways to ensure that pets, children, and others cannot consume them. However, you should not flush this medicine down the toilet. Instead, the best way to dispose of your medications is through a drug take-back program. Talk to your pharmacist or contact your local garbage / recycling department to find out about take-back programs in your community. See the FDA Safe Drug Disposal website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

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It is important to keep all medicines out of the sight and reach of children, since many containers (such as those containing weekly pills and those for eye drops, creams, patches and inhalers) are not resistant to children and small children can easily open them. To protect young children from poisoning, always close the safety caps and immediately place the medicine in a safe place, one that is upright and out of their sight and reach. http://www.upandaway.org

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim collapsed, had a seizure, is having trouble breathing, or is unable to wake up, immediately call 911 for emergency services.

Symptoms of overdose may include:

  • nausea
  • vomiting
  • constipation
  • sweating
  • pale skin
  • general feeling of discomfort or uneasiness
  • lack of energy
  • fainting
  • dizziness
  • drowsiness
  • confusion
  • hallucinations (seeing things or hearing voices that do not exist)
  • believing things that are not true
  • yawning repeatedly

What other information should I know?

Keep all appointments with your doctor, eye doctor, and the laboratory. Your blood pressure should be checked regularly. Your doctor may order regular eye exams and certain lab tests to check your body’s response to Bromocryptine. Your blood sugar and glycosylated hemoglobin (HbA1c) should be monitored regularly to determine your response to Bromocryptine (Cycloset). Your doctor will also tell you how to check your response to Bromocryptine (Cycloset) by measuring your blood or urine sugar levels at home. Follow these instructions carefully.

Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.

It is important that you keep a written list of all prescription and over-the-counter (over-the-counter) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should take this list with you each time you visit a doctor or if you go into hospital. It is also important information to take with you in case of emergencies.

Brand Names

Other Names

  • Bromocryptine
  • Brom-ergocryptine
  • 2-Bromoergocryptine
  • 2-Br-alpha-ergocryptine

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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