Simulect : Uses, Side Effects, Interactions & More

Simulect should be given only in a hospital or clinic under the supervision of a doctor who is experienced in treating transplant patients and prescribing medications that decrease the activity of the immune system.

Why is this medication prescribed?
Simulect (Basiliximab Injection) is used with other medications to prevent immediate transplant rejection (attack of the transplanted organ by the immune system of the person receiving the organ) in people who receive kidney transplants. Simulect belongs to a class of medications called immunosuppressants. It works by decreasing the activity of the body’s immune system so that it does not attack the transplanted organ.

How should this medicine be used?
Simulect (Basiliximab Injection) comes as a powder to be mixed with water and injected intravenously (into a vein) by a doctor or nurse in a hospital or medical facility. It is usually administered in 2 doses. The first dose is usually given 2 hours before transplant surgery, and the second dose is usually given 4 days after transplant surgery.

Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before receiving Simulect,

  • Tell your doctor and pharmacist if you are allergic to Simulect, any other medications, or any of the ingredients in Simulect. Ask your pharmacist for a list of the ingredients.
  • Tell your doctor and pharmacist what other prescription and over-the-counter medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • Tell your doctor if you have ever been treated with Simulect in the past and if you have or have ever had any medical conditions.
  • Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while receiving Simulect. Talk to your doctor about birth control methods that you can use before starting your treatment, during your treatment, and for 4 months after your treatment.
  • Tell your doctor if you are breastfeeding.
  • Don’t get vaccinated without talking to your doctor.
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What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.

What side effects can this medication cause?

Simulect may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • diarrhea
  • constipation
  • stomach pain
  • heartburn
  • swelling of the hands, feet, ankles, or lower legs
  • runny nose
  • headache
  • shaking of a part of the body that you cannot control
  • difficulty falling asleep or staying asleep
  • pain in the place where you received the injection

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • hives
  • rash
  • itching
  • sneezing
  • cough
  • wheezing
  • difficulty breathing or swallowing
  • fast heartbeat
  • muscle aches
  • fatigue
  • lightheadedness, dizziness, or fainting
  • weight gain and swelling all over the body
  • sore throat, fever, chills, or other signs of infection
  • difficult or painful urination
  • decreased urination

Simulect may increase the risk of developing an infection or cancer. Talk to your doctor about the risks of taking this medication.

Simulect may cause other side effects. Call your doctor if you have any unusual problems while taking this medicine.

If you experience a serious side effect, you or your doctor can submit an online report to the Food and Drug Administration (FDA) MedWatch Adverse Event Reporting Program ( or by phone (1-800-332-1088).

In case of emergency/overdose
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim collapsed, had a seizure, is having trouble breathing, or cannot wake up, call 911 immediately.

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What other information should I know?
Ask your pharmacist any questions you have about Simulect.

It is important that you keep a written list of all prescription and over-the-counter (non-prescription) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should carry this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand Names

  • Simulect

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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